The manuscript contains, for the most part, discourses on natural history and scientific and medical phenomena found in Scotland, taken from manuscript and printed sources.
Accounts taken from printed sources include ‘Philosophical Transactions’, ‘Description of the Islands of Orkney’ and ‘Large Description of Galloway’. Manuscript sources include letters and extracts of letters to Sibbald from Dr George Garden of Aberdeen and Matthew MacKaile, an Aberdeen apothecary.
At the end of the volume are copies of reviews of several of Sibbald`s publications and writings (page 493).