The letters here evidence the relationship between the archaeologist Austen Henry Layard and the publishing house of John Murray that lasted for over half a century. During that time, John Murray published works written by Layard about his excavations and other work.

The letters demonstrate the close nature of this relationship and give insight into his involvement with the publication process. Topics covered in the correspondence include news of the excavations undertaken by Layard, comments and concerns about the proofs and engravings for his works, and other details about his travels and life.